https://www.sciencedirect.com/science/article/pii/S1567576918313286?via%3Dihub
https://www.ncbi.nlm.nih.gov/pubmed/30738291?dopt=Abstract
Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome.
Int Immunopharmacol
Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome.
Int Immunopharmacol. 2019 Feb 06;69:213-216
Authors: Zhao J, Wang J, Zhou M, Li M, Li M, Tan H
Abstract
Despite rapid progress in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for novel and more effective interventions. Curcumin, a natural polyphenol compound, has been shown to be anti-inflammatory in various disorders. In this study, we investigated the potential therapeutic value of curcumin in SLE. Lupus-prone female MRL/lpr mice were treated with curcumin. The development and extent of nephritis were assessed by monitoring proteinuria and by histologic analysis. Serum anti-dsDNA levels were measured by enzyme-linked immunosorbent assay. Kidney samples were analyzed by Western blot. In vitro, mouse podocytes were used for investigation in the presence of mouse anti-dsDNA antibody-positive (anti-dsDNA+) serum. Curcumin treatment dramatically decreased proteinuria and renal inflammation. Serum anti-dsDNA levels and spleen size were also reduced by curcumin. In addition, curcumin reduced NLRP3 inflammasome activation in lupus-prone mice. In vitro, curcumin significantly inhibited anti-dsDNA+ serum induced expression of NLRP3 inflammasome in podocytes. Overall, these data demonstrate the potential use of curcumin in SLE treatment.
PMID: 30738291 [PubMed – as supplied by publisher]
PubMed:30738291
